General Information

  • ID:  hor003024
  • Uniprot ID:  NA
  • Protein name:  neuromedin U-8
  • Gene name:  NA
  • Organism:  Gallus gallus
  • Family:  NmU family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  YFLFRPRN
  • Length:  8
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T8 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  smooth muscle contractile activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003024_AF2.pdbhor003024_ESM.pdb

Physical Information

Mass: 123732 Formula: C54H77N15O11
Absent amino acids: ACDEGHIKMQSTVW Common amino acids: FR
pI: 11.15 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -75 Boman Index: -2574
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 48.75
Instability Index: 3882.5 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  1804545
  • Title:  Agonistic and Antagonistic Activities of Neuromedin U-8 Analogs Substituted With Glycine or D-amino Acid on Contractile Activity of Chicken Crop Smooth Muscle Preparations